Mario Capecchi, Ph.D.
Investigator, Howard Hughes Medical Institute Co-Chairman of the Department of Human Genetics Professor, Human Genetics Adjunct Professor, Oncological Sciences.
RESEARCH SUMMARY
Our research efforts are directed towards the analysis of the developmental programs mediating pattern formation, organogenesis and neurogenesis in the mouse. Towards achieving these goals, we have pioneered the technology required for generating mutations in any gene in the mouse. This technology employs the exchange of DNA sequences, by homologous recombination, between exogenous, newly added DNA sequences and the cognate chromosomal DNA sequences in embryo-derived mouse stem (ES ) cells. This process is referred to as "gene-targeting". We are using this technology to determine the function of genes believed to mediate important developmental decisions in the mouse embryo. Eventually, the technology should also provide an avenue for directly correcting genetic defects in humans via somatic gene therapy.
BIOGRAPHY
Please see the lab website below.
LABORATORY
INFORMATION
http://capecchi.genetics.utah.edu
