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Carl Thummel, Ph.D. Investigator, Howard Hughes Medical Institute Professor, Human Genetics RESEARCH SUMMARY & GOALS Our lab is studying the molecular mechanisms of steroid hormone action during development. Biochemical and functional studies of vertebrate nuclear hormone receptors have led to extensive characterization of their hormone and DNA binding properties and effects on transcription. Our understanding of the later steps in hormone action, however, is relatively primitive; we know that hormones control growth, metabolism, and development, but the actual molecular mechanisms involved remain obscure. We have chosen the fruit fly, Drosophila melanogaster, as a model system for studying the molecular mechanisms of steroid hormone action. BIOGRAPHY text to be added later. LABORATORY INFORMATION: thummel.genetics.utah.edu |
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